Product Description

Product name:conolidine
CAS: **********1
Molecular formula: C*7H*8N2O
Description:Conolidine is an alkaloid. Preliminary reports suggest that it could provide analgesic effects with few of the detrimental side-effects associated with opioids such as morphine, though at present it has only been evaluated in mouse models.

Conolidine was first isolated in ***4 from the bark of the Tabernaemontana divaricata (Crepe jasmine) shrub which is used in traditional Chinese medicine.

A method for creating synthetic conolidine from a commercially available acetyl-pyridine in 9 steps was developed by Micalizio, Bohn, and coworkers in ***1. This synthetic route allows access to either enantiomer (mirror image) of conolidine via an early enzymatic resolution. Notably, both enantiomers of the synthetic compound show analgesic effects.