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Country:
China
Model No:
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FOB Price:
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Delivery Time:
1 week
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Contact Person Ms. Linlin
Xinyang, Xiamen, Fujian
The
AmoyDx EML*-ALK Fusion Gene Detection Kit is a
sensitive and selective assay for the detection of
the twenty-one most common fusion transcripts of the chimeric
EML*-ALK gene.
The EML*-ALK fusion oncogene represents one of the newest molecular targets in non-small-cell lung cancer (NSCLC). First described in ***7, the fusion results from a small inversion within chromosome 2p. This inversion leads to expression of a chimeric tyrosine kinase having the N-terminal half of echinoderm microtubule-associated protein-like 4 (EML4) fused to the intracellular kinase domain of anaplastic lymphoma kinase (ALK). The EML*-ALK protein possesses potent oncogenic activity both in vitro and in vivo. This activity can be blocked by small-molecule inhibitors, supporting a role for EML*-ALK as a key driver of lung tumorigenesis.
Intended
Use:
CE marked for IVD use in Europe and CFDA approved for clinical use
in China.
Technological Principles:
The EML*-ALK kit employs proprietary real-time PCR technology to
detect the twenty-one most common EML*-ALK fusion transcripts.
RNA that has been purified from the FFPE tissue is first reverse
transcribed to cDNA with RT enzyme supplied with the kit. The
EML*-ALK fusion cDNAs are then specifically amplified with
cross-junction PCR primers and quantitatively detected with
fluorescent probes.
AmoyDx EML*-ALK Fusion Gene Detection Kits are available in the following size, minimum order of *2 tests:
Product Name |
Size (tests/kit) |
Storage |
Cat. No. |
EML*-ALK Fusion Gene Detection Kit (pre-loaded) |
*4T |
**0oC |
ADx-AE*1 |
EML*-ALK Fusion Gene Detection Kit (bulk) |
*2T |
**0oC |
ADx-AE*2 |
Key Features and Benefits:
• Simple Procedure — only one step required for
sample application, results obtained within *0 minutes.
• High sensitivity and accuracy — can detect 1%
mutant DNA in a background of wild type genomic DNA.
• ADx-ARMs technology — employs a patented
two-step PCR amplification procedure and novel fluorescent probe
design.
• Easy Standardization — any general PCR lab can
perform the test, and technicians obtain reproducible results
without specialized training.
• Reliable product quality — Produced in a
dedicated GMP plant, with quality management systems that have
passed Chinese SFDA and international ISO****5
standards.
• Sample type: FFPE tissue; also fresh or frozen tissue.
Country: | China |
Model No: | - |
FOB Price: | Get Latest Price |
Place of Origin: | - |
Price for Minimum Order: | - |
Minimum Order Quantity: | - |
Packaging Detail: | - |
Delivery Time: | 1 week |
Supplying Ability: | - |
Payment Type: | - |
Product Group : | Gene Fusions Detection Kit |