Product Description

MP  ******0 °C(lit.)
alpha  **4 º (c=1, dimethylform) 
storage temp.  −*0°C
Water Solubility  practically insoluble 
Merck  *4,***9 
BRN  ****6 
Griseofulvin pure product is colorless crystal, being neutral, and insoluble in water with a strong systemic property. It is stable both in vitro and in vivo of plants and is also stable to the various environment factors between pH3.0 ~ 8.8. It can be used for prevention and treatment of a variety of fungal plant diseases. The main species china applied for production of griseofulvin is Penicillium nigricans and Penicillium urticae. When grown at the medium, Penicillium nigricans is fuzzy with fresh culture being pure gray and aging culture being dark gray with its back being deep orange-red to the back orange brown. The fungi lawn of Penicillium urticae is yellowish green to pure light gray, thick and dense with the back being pale yellow to brownish; their aerial hyphae has a broom-like shape.


Usage:
1) adrenegic blocker, Ca channel blocker, coronary vasodilator, antiarrhythmic
2) antifungal, inhibits mitosis in metaphase
3) Griseofulvin is a spirobenzofuran produced by a number of Penicillium species, first isolated in the ***0s by Raistrick's group. Griseofulvin is a selective antifungal agent used to treat skin infections in animals and humans. Griseofulvin acts by binding to fungal tubulin and inhibiting the mitotic spindle. Griseofulvin's ability to bind to keratin is considered an important aspect of the metabolite's access to dermatophytic fungi. More recently, griseofulvin has become an important phenotypic marker in Penicillium taxonomy.
4) It is an antifungal drug. It is used both in animal and in humans, to treat rigworm infections of the skin and nails. It is derived from the mold Penicillium griseofulvum

Medical uses
Griseofulvin is used orally only for dermatophytosis. It is ineffective topically. It is reserved for cases with nail, hair, or large body surface involvement.

Pharmaceutical raw materials   An anti-fungal and anti-proliferative agent that affects microtubules

Griseofulvin, an antifungal agent, has been reported to inhibit proliferation of various types of cells. This compound has also been shown to strongly suppress the dynamic instability of individual microtubules via reduction of the rate and extent of the growing and shortening phases. The effects that Griseofulvin has on microtubules can cause mitotic arrest and abnormalities, such as multipolar spindles, misaligned chromosomes, and fragmented nuclei

Application for Griseofulvin
1) Griseofulvin is an antifungal drug that is administered orally. It is used both in animals and in humans, to treat fungal infections of the skin (commonly known as ringworm) and nails. 
2) Potential for cancer treatment   
3) Griseofulvin is used orally only for dermatophytosis

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