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 Home > Sell Offers > Sell FK520/Ascomycin, Tacrolimus, Rapamycin/Sirolimus, MMF/MMA, CsA
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North China Pharmaceutical Group Corporation New Drug R&D CO., Ltd

    

Sell FK520/Ascomycin, Tacrolimus, Rapamycin/Sirolimus, MMF/MMA, CsA


[China]
Posted Date: February 21, 2008    Expiry Date: February 21, 2009
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Description
Ascomycin (FK520) is a structurally complex macrolide with immunosuppressant activity. It is an ethyl analog of the known immune suppressant FK506 (Tacrolimus).1, 2 Ascomycin acts by binding to a class of cytosolic proteins, the immunophilins, especially macrophilin-12 (FKBP-12). The immunophilin-FK520 complex inhibits calcineurin, a type 2B phosphatase (PP2B).3, 4

Ascomycin suppress the production of Th1 and Th2 cytokines in T lymphocytes, and preferentially inhibits the activation of mast cells (principal cells of the allergic response).5 In human basophils, it potently inhibited anti-IgE-induced histamine and cytokine release, and reduced IgE-dependent p38 MAPK activation.6 It seems that Ascomycin inhibit basophil degranulation at the initial phase of allergic skin reactions.7, 8 Ascomycin derivatives are currently developed for the clinical treatment of dermatological diseases.9, 10


M.W.: 792.00

CAS No.: [11011-38-4]


Purity: >99%
 
Other Information
Location:  China 
Minimum Order:  not limited 
Price for Minimum Order:   
  (This price is only for minimum order. for large quantities, please contact)
Sample Available:  YES 
Price for Sample:   
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Related Categories: Pharmaceutical Chemicals
Related Products: fk506, tacrolimus »
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