FOB Price
Get Latest Price1 ~ 400 / Kilogram ( Negotiable )
|1 Gram Minimum Order
Country:
China
Model No:
Alpha GPC 99%
FOB Price:
1 ~ 400 / Kilogram ( Negotiable )Get Latest Price
Place of Origin:
China
Price for Minimum Order:
1 per Kilogram
Minimum Order Quantity:
1 Gram
Packaging Detail:
25kg/drum
Delivery Time:
15 days after payment
Supplying Ability:
30 Metric Ton per Month
Payment Type:
T/T, L/C, Western Union
Product Group :
China
Contact Person Ms. Jennifer
No.100 Jinxi Road, Wuxi, Jiangsu
Brain anti-aging
nutrition
Brain health food
Choline Alfoscerate powder
Formula: C8H*0NO6P
MW: **7
Appearance: White to light yellow fine powder
Purity: *9% min
Packing: 5kg/foil bag; *5kg/drum
Store: Keep away from fire and heat source; hermetically
deposit; keep in shady, cool and dry condition; protect against the
tide.
Choline Alfoscerate Liquid
Properties: colorless
transparent liquid. Soluble in water and organic solvents.
Molecular formula: C8H*0NO6P
Choline Alfoscerate (GPC) L-alfa-glycerylphosphorylcholine
L-alfa-GPC
CAS No. :*********9
Choline
alfoscerate (also known as Alpha-GPC) is L-a-glyceryl
phosphorylcholine (GPC),a key brain cell membrane phospholipid and
cholinergic precursor. It is a source of choline for the synthesis
of the neurotransmitter acetylcholine, with a greater ability to
penetrate the blood-brain barrier than conventional choline
sources.
More importantly,
Choline alfoscerate has been experimentally demonstrated to reduce
or reverse agerelated structural changes in the frontal cortex and
hippocampus andinducedfunctional
deficiencies of the cholinergic system. Research supports choline
alfoscerate's ability to support healthy brain function and the
release of somatotrophin (hGH).
Main
Applications of Choline alfoscerate
:
As reported by
literature:
Support in Alzheimer’s
disease.
Cognitive
support.
Infant brain
development.
Choline alfoscerate (al-FOSS-er-ate), or alpha-glycerylphosphorylcholine (GPC), is a phospholipid - a complex fatty substance containing phosphorus, like phosphatidylserine and phosphatidylcholine - and is an important building block in the construction ofnerve cell membranes. After completing an analysis of thirteen published clinical trials, involving over ***0 patients, a group of Italian scientists concluded that "The stated therapeutic usefulness of Choline Alfoscerate in the relief of cognitive symptoms, such as memory and attention impairment, differentiates [it] from cholinergic precursors used in former clinical trials", such as choline, lecithin, or phosphatidylcholine. The reason, as evidence now suggests, is that the effects of this versatile nutrient extend well beyond its role as a mere choline source: choline alfoscerate supports the restoration of a whole spectrum of youthful cholinergic functions.
Weak Link
1: Decreased Choline Uptake
Choline alfoscerate is a
rapidly absorbed source of choline, which easily enters the brain.
GPC raises free plasma choline more rapidly than other uncharged
choline precursors. Because it is a phospholipid - the same sort of
material of which the brain and Blood-Brain Barrier (BBB) are made
-Choline Alfoscerate does not carry the electrical charge of
regular choline, and so freely crosses the blood-brain barrier. The
choline from Choline Alfoscerate is
incorporatedinto brain phospholipids within *4 hours of absorption.
Weak Link
2: Enzyme Imbalances
The brain makes
acetylcholine using an enzyme known as choline acetyltransferase.
As we get older, ChAT activity goes down, while the activity of
enzymes that break down chat goes up. As a result, aging brains
make less acetylcholine from the choline available to them, while
they tear acetylcholine down more quickly. Animal studies suggest
that Choline Alfoscerate may also improve the levels of
ChAT.
Weak Link 3: Brain
Drain
This is perhaps the most
serious issue facing the aging brain: the cholinergic neurons of
the brain simply wither away with age. The number of neurons
declines, and those neurons that remain literally shrink, becoming
less well-connected to the rest of the brain. This decay is made
all the worse by the fact that the ability of the surviving
cholinergic neurons to release and respond to ACh is also impaired
with age!
Even more
incredibly, animal studies show that Choline Alfoscerate actually
increases the number of cholinergic neurons as well. In addition,
Choline Alfoscerate may reverse the atrophy of existing cholinergic
neurons, since studies show that Choline Alfoscerate increases the
number of receptors for nerve growth factor (NGF). Supplying NGF to
old monkeys clearly reverses cholinergic neuron atrophy, restoring
the number and size of these neurons to more youthful
levels.
Controlled Trials: It
Works
In one controlled trial
in victims of vascular dementia, greater improvements on several
measures of cognitive function were seen amongst those patients
treated with Choline Alfoscerate than in those given another
choline precursor. The differences were statistically significant,
and both patients and physicians rated the results with GPC more
satisfactory.
Another controlled trial
in Alzheimer's disease compared Choline Alfoscerate to
acetyl-L-carnitine (ALCAR), a nutrient already proven to slow the
progression of AD in younger patients. Most behavioral and mental
function test results showed improvement in the Choline Alfoscerate
group - and the improvements were greater than those seen in the
ALCAR group.
There is
also a hint that Choline Alfoscerate may prove of use in
Parkinson's disease (PD). PD is characterized by reductions in the
production of the neurotransmitter dopamine in an area of the brain
called the substantia nigra. This leads to a loss of motor control,
typically manifesting in facial ticks or tremors, dry mouth, and a
"masklike" facial expression. In laboratory animals, measures of
dopaminergic activity were enhanced by GPC
treatment.
Choline alfoscerate, or L-Alpha Glycerylphosphorylcholine (Alpha GPC), occurs naturally in the fatty acids of soy plants. It is considered important to the synthesis of acetylcholine, a neurotransmitter that supports brain health and the production ofhuman growth hormone(HGH). As the brain ages, acetylcholine levels typically decrease, which can lead to cognitive disorders such asdementia and Alzheimer's. Studies suggest that choline alfoscerate can treat Alzheimer's and other forms of age-related cognitive decline. Evidence also suggests that this type of choline may be able to stimulate increased blood levels of human growth hormone in the elderly, for a healthier, more youthful body.
Alpha-GPC is marketed in the United States as adietary supplement. Prescription forms ofcholine alfoscerate are administered in Europe to treat Alzheimer's disease. Dementia, stroke, and transient ischemic attack (TIA) patients may also benefit from alpha GPC use. Alpha-GPC is marketed as a dietary supplement that can enhance memory, cognitive ability and learning ability.
Unlike some other forms of choline, choline alfoscerate normally penetrates the blood-brain barrier easily. Once it has crossed the blood-brain barrier, the brain makes acetylcholine from alpha-GPC. Acetylcholine is an important neurotransmitter that is believed responsible for memory, learning, normal cognitive function and human growth hormone production.
As the brain ages, its neurons and neural receptors can atrophy, ceasing to function. Aging brains often experience significant declines in the function of memory-specific neural receptors. Choline alfoscerate may help to stimulate the growth of new neurons and neural receptors, and may help reverse the neural atrophy that can cause loss of cognitive function. As a result, alpha-GPC may be able to slow, stop, or reverse cognitive decline in those already suffering from Alzheimer's, dementia or other forms of age-related cognitive decline. It is hoped that choline alfoscerate may prove invaluable to the treatment of Alzheimer's, dementia and other age-related cognitive disorders.
Choline alfoscerate may also help boost production of human growth hormone in the elderly. While the production of human growth hormone in the brain doesn't typically decline with age, its release into the body can decline significantly. Choline alfoscerate can help stimulate the release of human growth hormone in the brains of older patients. Higher levels of HGH release can help keep elderly patients physically strong and healthy.
Country: | China |
Model No: | Alpha GPC 99% |
FOB Price: | 1 ~ 400 / Kilogram ( Negotiable ) Get Latest Price |
Place of Origin: | China |
Price for Minimum Order: | 1 per Kilogram |
Minimum Order Quantity: | 1 Gram |
Packaging Detail: | 25kg/drum |
Delivery Time: | 15 days after payment |
Supplying Ability: | 30 Metric Ton per Month |
Payment Type: | T/T, L/C, Western Union |
Product Group : | Nutrition supplement |