Product Description

Product name:Costundide
CAS:*******9
Purity:HPLC≥*8%
Specification:*0mg
Product Description:(+)-Costunolide is a sesquiterpene lactone that is synthesized through the mevalonate pathway, seen in Figure 1. The synthesis begins with the cyclization of compound 1, farnesyl pyrophosphate (FPP), which is mediated by a sesquiterpene cyclase, (+)-germacrene A synthase, to form compound 2, (+)-germacryl cation.Inside this same enzyme, a proton is lost to form 3, (+)-germacrene A.The isoprenyl side chain of (+)-germacrene A is then hydroxylated by (+)-germacrene A hydroxylase, which is a cytochrome P**0 enzyme, to form 4.[1] NAD(P)+ dependent hydrogenase(s) then oxidize 4, germacra*1(*0),4,*1(*3)-trien***-ol, through the intermediate 5, germacra*1(*0),4,*1(*3)-trien***-al to form compound 6, germacrene acid. The cyctochrome P**0 enzyme, (+)-costunolide synthase, which is a NADPH and O2 dependent enzyme, then oxidizes germacrene acid to give the alcohol intermediate, 7, which then cyclizes to form the lactone 8, (+)-costunolide.