Product Description

1. English name: Diosmin;

2. Active ingredients: Diosmin;

3. Origin: Citrus Aurantium L.

4. Appearance: Greyish-yellow or light yellow hygroscopic powder;

5. Specification:

    Diosmin *0% EP 8.0

    Diosmin *0% EP 8.3

    Diosmin *2%

    Diosmin *4%

    Diosmin & Hesperidin 9:1

6. Test Method: HPLC; IR;

7. CAS NO.:  *******3;

8. Molecular Weight: **8.**5 g/mol 

9. Diosmin brief introduction:



Diosmin is semisynthetic drug (modified hesperidin). It is an oral phlebotropic drug used in the treatment of venous disease, i.e., chronic venous insufficiency(CVI) and hemorrhoidal disease (HD), in acute or chronic hemorrhoids, in place of rubber-band ligation, in combination with fiber supplement, or as an adjuvant therapy to hemorrhoidectomy, in order to reduce secondary bleeding. To control internal symptoms of hemorrhoids(piles), it is used with hesperidin.



Clinical studies have been inconclusive and no review articles on its use in vascular disease have been published.



Diosmin is currently a prescription medication in some European countries (under the Dio-PP, Venotec, Daflon etc. tradenames), and is sold as a nutritional supplement in the United States and the rest of Europe.



Diosmin has been found to be effective in mitigating hyperglycemia in diabetic rats.It is also speculated that diosmin might have potential in the treatment of neurodegenerative diseases, such as Alzheimer's disease, and its anti-inflammatory and anti-apoptotic activity has been demonstrated in neuronal cells, in vitro.



*0. Diosmin main functions:

 

1). Treatment of venous lymphatic insufficiency associated symptoms (heavy legs, pain, discomfort, soreness early morning) - the treatment of acute hemorrhoid attack on a variety of symptoms.



 2). With vitamin P-like effects, can reduce vascular fragility and abnormal permeability, but also for the control of the adjuvant treatment of hypertension and arteriosclerosis, for the treatment of capillary fragility was better than rutin, hesperidin and stronger, and has low toxicity characteristics.



 3). Of the vein system to play its active role in: - reduce venous distensibility and venous stasis zone.



 4). In the micro-circulatory system, so that the normalization of capillary wall permeability and increase their resistance.