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Qufu Liyang Biological Products Co., Ltd

3/F, Tourist Centre, Jingxuan East Road, Qufu City,Jining,Shandong,China

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Hyaluronic acid, hyaluronan, sodium hyaluronate

China

cosmetic grade

300 ~ 500 / Kilogram Get Latest Price

-

300 per Kilogram

1 Kilogram

ikg/bag

3days

1000 Kilogram per Month

Other, PayPal, Money Gram, Western Union, D/P, D/A, L/C, T/T

cosmetic grade

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Product Specification

Brand Name : QUFULIYANG Type : -
form : powder CAS : 9004-61-9 HS : 3913900000 EINECS : 232-678-0

Product Description

Alex

 
Functions Of Hyaluronan
Until the late 1970s, hyaluronan was described as a "goo" molecule, a ubiquitous carbohydrate polymer that is part of the extracellular matrix. For example, hyaluronan is a major component of the synovial fluid, and was found to increase the viscosity of the fluid. Along with lubricin, it is one of the fluid's main lubricating components.
Hyaluronan is an important component of articular cartilage, where it is present as a coat around each cell (chondrocyte). When aggrecan monomers bind to hyaluronan in the presence of link protein, large, highly negatively charged aggregates form. These aggregates imbibe water and are responsible for the resilience of cartilage (its resistance to compression). The molecular weight (size) of hyaluronan in cartilage decreases with age, but the amount increases.
Hyaluronan is also a major component of skin, where it is involved in tissue repair. When skin is exposed to excessive UVB rays, it becomes inflamed (sunburn) and the cells in the dermis stop producing as much hyaluronan, and increase the rate of its degradation. Hyaluronan degradation products then accumulate in the skin after UV exposure.
While it is abundant in extracellular matrices, hyaluronan also contributes to tissue hydrodynamics, movement and proliferation of cells, and participates in a number of cell surface receptor interactions, notably those including its primary receptors, CD44 and RHAMM. Upregulation of CD44 itself is widely accepted as a marker of cell activation in lymphocytes. Hyaluronan's contribution to tumor growth may be due to its interaction with CD44. Receptor CD44 participates in cell adhesion interactions required by tumor cells.
Although hyaluronan binds to receptor CD44, there is evidence hyaluronan degradation products transduce their inflammatory signal through toll-like receptor 2 (TLR2), TLR4 or both TLR2, and TLR4 in macrophages and dendritic cells. TLR and hyaluronan play a role in innate immunity.
High concentrations of hyaluronan in the brains of young rats, and reduced concentrations in the brains of adult rats suggest hyaluronan plays an important role in brain development.

Contact Us

Contact Person :Ms. Xu

Company:Qufu Liyang Biological Products Co., Ltd

Address:3/F, Tourist Centre, Jingxuan East Road, Qufu City, Jining, Shandong, China,273100

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Ms. Xu < Qufu Liyang Biological Products Co., Ltd >
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