Product Description

Milk Thistle Extract is extracted from thedried seeds or fruit of Silybum marianum L. Gaertn. It has many pharmacological effects includinghepatoprotective, antioxidant, anti-inflammatory, antifibrotic and antitumour properties.Silymarin, particularlysilybinin, are responsible for the pharmacological effects.

 

EP/USP/DAB Standard

Silymarin UV*0%, Yellowish brown, amorphous powder, consisting of,

 ****5% of Silychristin & Silydianin, 

 ****5% of Silybin A&B,

 ****0% of Isosilybin A&B.

Regular Specification

Silymarin UV*0%, HPLC****5%;

Silymarin UV*0%, Silybin HPLC*0%, or Silybin&Isosilybin HPLC*0%

Antioxidant activity

Silymarin and silibinin (silybin) are antioxidants that react with free radicals (e.g. reactive oxygen species) transforming them into more stable and less reactive compounds.

Hepatoprotective properties

In vitro studies using isolated hepatocytes have documented the protective activity of silymarin and several of its components against cell damage induced by various cytotoxic substances.

Anticancer activity

Silybin at concentrations of 0.**0 mmol/L inhibited the growth of drug-resistant ovarian cancer cells and breast cancer cells in vitro.

Anti-inflammatory activity

Silymarin administered orally reduced foot-pad abscesses in a dose dependent manner in the carrageenan rat-paw oedema test.

Gastric ulcer protective effects

Oral administration of silymarin to rats prevented gastric ulceration induced by cold-restraint stress.

Other effects

Silymarin has been shown to prevent alloxaninduced diabetes mellitus in rats, possibly due to its antioxidant activity and increases in plasma and pancreatic glutathione concentrations.

Recommended Use

The recommended dosage is **0 mg of silymarin (******0 mg of extract), **3 times daily. In clinical trials, the daily oral dose of silymarin used ranged from **0 to **0 mg. This is equivalent to **0 to ***0 mg of standardised extract containing ****0% silymarin.