FOB Price
Get Latest Price500 ~ 550 / Bag
|- Minimum Order
Country:
Ethiopia
Model No:
-
FOB Price:
500 ~ 550 / Bag Get Latest Price
Place of Origin:
-
Price for Minimum Order:
500 per Bag
Minimum Order Quantity:
-
Packaging Detail:
by bag
Delivery Time:
by container
Supplying Ability:
2000 Bag per Year
Payment Type:
Western Union
Product Group :
-
Contact Person Ejara
Addis Ababa, Addis Ababa
Abstract
The roots
of Withania somnifera (WS) are used extensively in Ayurveda, the
classical Indian system of medicine, and WS is categorized as a
rasayana, which are used to promote physical and mental health, to
provide defence against disease and adverse environmental factors
and to arrest the aging process. WS has been used to stabilize mood
in patients with behavioural disturbances. The present study
investigated the anxiolytic and antidepressant actions of the
bioactive glycowithanolides (WSG), isolated from WS roots, in rats.
WSG (*0 and *0 mg/kg) was administered orally once daily for 5 days
and the results were compared by those elicited by the
benzodiazepine lorazepam (0.5 mg/kg, i.p.) for anxiolytic studies,
and by the tricyclic anti-depressant, imipramine (*0 mg/kg, i.p.),
for the antidepressant investigations. Both these standard drugs
were administered once, *0 min prior to the tests. WSG induced an
anxiolytic effect, comparable to that produced by lorazepam, in the
elevated plus-maze, social interaction and feeding latency in an
unfamiliar environment, tests. Further, both WSG and lorazepam,
reduced rat brain levels of tribulin, an endocoid marker of
clinical anxiety, when the levels were increased following
administration of the anxiogenic agent, pentylenetetrazole. WSG
also exhibited an antidepressant effect, comparable with that
induced by imipramine, in the forced swim-induced 'behavioural
despair' and 'learned helplessness' tests. The investigations
support the use of WS as a mood stabilizer in clinical conditions
of anxiety and depression in Ayurveda.
Country: | Ethiopia |
Model No: | - |
FOB Price: | 500 ~ 550 / Bag Get Latest Price |
Place of Origin: | - |
Price for Minimum Order: | 500 per Bag |
Minimum Order Quantity: | - |
Packaging Detail: | by bag |
Delivery Time: | by container |
Supplying Ability: | 2000 Bag per Year |
Payment Type: | Western Union |
Product Group : | - |