WS*5 (CAS *********8) Product Introduction, Applications and
Advantages 1. Product Introduction
WS*5, with the chemical name
(1R*,2S*,5R*)-N-(*-methoxyphenyl)**-methyl**-(*-methylethyl)cyclohexanecarboxamide,
is a high-purity synthetic cooling agent specifically developed
for industrial, food, and daily chemical applications. It
appears as a white to off-white crystalline powder, featuring a
mild and fresh mint-like odor without any pungent or bitter
taste, which distinguishes it from traditional menthol-based
cooling agents. With a molecular formula of C₁₈H₂₇NO₂ and a
molecular weight of **9.*1 g/mol, it possesses stable chemical
properties and excellent compatibility with various raw
materials, solvents, and product systems.
As a potent TRPM8 channel agonist, WS*5 can specifically
activate the transient receptor potential melastatin 8 (TRPM8)
channel, thereby generating a clear, gentle, and long-lasting
cooling sensation. It is widely recognized in the industry as a
high-performance, safe, and efficient cooling additive. Meeting
international quality standards, it has a purity of not less
than *9% (detected by HPLC), a melting point of approximately
**8°C, a boiling point of **7.8±*8.0°C, and a density of
1.**9±0.*6 g/cm³ at *5°C, which ensures stable performance in
various application scenarios and long-term storage.
2. Applications
Benefiting from its excellent cooling performance, high safety,
and good compatibility, WS*5 is widely applied in multiple
fields, with specific applications detailed as follows:
- Tobacco and E-cigarette Industry: It is an ideal cooling
additive for cigarette flavoring, e-cigarette oil, and hookah
flavor formulations. When added in an appropriate proportion
(0.1%*0.5%), it can effectively soften the smoke, reduce the
irritation of tobacco smoke, enrich the taste hierarchy, and
avoid covering the inherent flavor of tobacco. It brings a
fresh and cool smoking experience without affecting the
original aroma of tobacco products. Additionally, it is
suitable for various tobacco-related products such as cigarette
filters, further enhancing the comfort of use.
- Food and Beverage Industry: It is widely used in food and
beverage products that require a cooling taste, including
candies, chocolates, dairy products, carbonated drinks, herbal
teas, chewing gums, and baked goods. The recommended addition
amount ranges from 0.*1% to 0.2%: adding it to candies and
chocolates can enhance the cool taste without compromising the
original flavor; adding it to beverages can bring a fresh and
refreshing taste, and it can also improve the taste of baked
goods by reducing greasiness. It is highly compatible with
various food raw materials and will not cause adverse reactions
such as stratification or precipitation.
- Daily Chemical and Oral Care Industry: It is extensively
used in oral care products such as toothpaste, mouthwash, and
oral sprays, as well as daily chemical products such as skin
care creams, lotions, wet wipes, and air fresheners. In oral
care products, it not only provides a long-lasting cool feeling
but also helps freshen breath and relieve oral dryness. In skin
care and daily chemical products, it delivers a comfortable
cool touch, relieves skin discomfort, and has good skin
compatibility without causing irritation.
- Pharmaceutical Industry: It can be used as an auxiliary
additive in pharmaceutical formulations, such as cooling
ingredients in plasters, lotions, and oral medicines. It helps
relieve local discomfort such as swelling and pain, and its
mild performance will not interact with other pharmaceutical
ingredients, ensuring the stability and effectiveness of the
medicine.
- Other Fields: It can be used as a cooling additive in
insect repellents, pet care products, and industrial cooling
materials. In insect repellents, it enhances the comfort of use
while maintaining the repellent effect; in pet care products,
it provides a cool and comfortable experience for pets without
causing harm; in industrial cooling materials, it plays a role
in temperature regulation due to its stable cooling
performance.
3. Product Advantages
Compared with traditional cooling agents (such as menthol,
WS**0, and WS**3), WS*5 has significant advantages in
performance, safety, and application scope, specifically as
follows:
- Strong and Long-lasting Cooling Effect: As a
high-efficiency TRPM8 agonist, WS*5 can generate a clear and
lasting cooling sensation with a low addition amount. The
cooling effect starts quickly and lasts for a long time, which
is **5 times that of traditional menthol, and there is no
obvious fading of the cooling sensation over time.
- Mild and Non-irritating: It has a gentle cooling sensation
without any pungent, bitter, or numbing taste, which solves the
problem of irritation caused by traditional cooling agents. It
is suitable for long-term use and has no adverse effects on the
human body, even when used in oral and skin care products.
- Excellent Chemical Stability: It has good thermal stability
and chemical stability, and is not easy to volatilize, oxidize,
or decompose under normal storage and application conditions
(temperature ****0°C, dry and ventilated environment). It can
maintain stable performance in various product formulations,
ensuring the consistency of product quality.
- Good Compatibility: It is highly compatible with various
raw materials, including flavor raw materials, alcohols,
propylene glycol, water, and other solvents, as well as food,
tobacco, daily chemical, and pharmaceutical raw materials. It
can be easily blended into various formulations without causing
stratification, precipitation, or discoloration, facilitating
industrial production and formula adjustment.
- High Safety and Compliance: It meets international food
grade, tobacco grade, and cosmetic grade standards, with no
toxicity, no irritation, no carcinogenicity, and no
mutagenicity. It has passed multiple safety tests and
certifications, and can be safely used in food, daily chemical,
and pharmaceutical products in accordance with the recommended
addition amount.
- No Interference with Original Flavor: When added to various
products, it only provides a cooling effect and does not cover,
alter, or affect the original flavor of the product. It can
better highlight the inherent flavor of the product while
enhancing the use experience, which is particularly suitable
for flavor-sensitive products such as tobacco and high-end
food.
- Wide Application Range: It is applicable to tobacco, food,
daily chemical, pharmaceutical, and other multiple fields, and
can meet the cooling needs of different types of products. Its
versatility and high applicability make it a preferred cooling
additive in the industry.
- Convenient Storage and Use: As a crystalline powder, it is
easy to store, transport, and measure. It has good flowability
and can be quickly dissolved in relevant solvents, which
simplifies the production operation process and improves
production efficiency.
