Description

Name  Corni Fructus Extract Latin Name Cornus officinalis seb.
Synonyms 
  Corni Fructus is Cornaceae Cornaceae, Cornus was
  born in thickets on slopes in habitat distribution.
  Located in Shaanxi, Shanxi,   Shandong, Anhui,
  Zhejiang, Sichuan province. North Korea also has.
Plant part used  fruit
Active Ingredient Loganin
Molecular Formula  C*7H*6O*0
Molecular Weight  **0.*9 g/mol
Specification  7%, *0%, *0%
Test Method HPLC
CAS No.  *********2
Study
Accumulating evidence indicates that uncontrolled diabetes leads to the progression of diabetic complications such as liver disorder. The present study was carried out to elucidate the protective role of loganin extracted from Corni Fructus against hepatic oxidative stress caused by type 2 diabetes. Loganin (*0 or **0mg/kg body weight/day, p.o.) was administered every day for 8 weeks to db/db mice, and its effect was assessed on comparison with vehicle-treated db/db and m/m mice. The administration of loganin led to a decrease in glucose and elevation of leptin in serum. The diabetic oxidative stress was attenuated by loganin through inhibitions of reactive oxygen species production and lipid peroxidation in the serum and liver. The expression of proteins induced by oxidative stress was significantly up-regulated in the liver of diabetic db/db mice; however, the expressions of both Nox*4 and p*2(phox) were decreased significantly by loganin administration. Loganin showed a crucial effect in the inflammation-activated signaling pathway through the regulation of NF-KB, COX*2, and iNOS. It was also found to regulate the anti-inflammatory factors Nrf*2 and HO*1 in hepatic tissue. Moreover, expression of MCP*1 was significantly down-regulated in the loganin-treated db/db mice. Furthermore, loganin administration showed a protective effect against apoptosis by the regulation of Bcl*2 and cytochrome c. The present study demonstrated that the administration of loganin isolated from Corni Fructus had a protective effect against hepatic oxidative stress under type 2 diabetes through regulations of protein expressions related to oxidative stress, inflammation, and apoptosis.
Main Function
  Blood glucose effects *- Loganin have antidiabetic effects, Loganin had significant hypoglycemic effect on alloxan and adrenaline four diabetic rats.
  Antibacterial *- loganin experiments showed that the fruit of Cornus officinalis decoction can inhibit the growth of Staphylococcus aureus, Escherichia coli, but the invalid.
  Inhibitory effect on platelet aggregation *- Cornus officinalis injection in vitro drug, can inhibit the threshold concentration of two adenosine monophosphate ( ADP ) in rabbit platelets sodium, collagen or four arachidonic acid induced aggregation, inhibitory effect as its amount increased.
Usage Dietary supplement; Medicine.
Shelf Life  2 years
Storage
  • Protected from light.