Description
As a recognized leader in the fields of phage display and antibody
engineering, Creative Biolabs is specialized in phage display
antibody library technology to make monoclonal rabbit, chicken,
llama, dog, monkey, mouse and human antibodies. Particularly, we
are proud to be the first and the only company to provide
monoclonal canine antibody generation services.
Based on our extensive experience in phage display library
construction and screening, scientists in Creative Biolabs have
created several immunized canine antibody libraries, from which we
have successfully isolated a number of high affinity antibodies
using panning techniques. Through this strategy, we can generate
custom monoclonal canine antibodies that have the potential for use
in a wide range of biomedical applications including the treatment
of malignant, infectious, inflammatory and autoimmune diseases in
dogs, which paves the way for exploration of such applications in
canine medicine.
As for antigens that are not suitable for immunization, we are also
pleased to make a custom synthetic canine antibody library for you
based on our full understanding of the canine antibody repertoires.
We can take the major framework sequence of light chain heavy chain
of canine antibody repertoires and then create mutations/variations
in all 6 CDR regions (or 2 CDR3 regions). Combined with various
mutation strategies, we can produce canine antibodies against any
antigens, including those that are toxic and of no immune response
in animals.
Besides developing monoclonal canine antibodies, Creative Biolabs
has also established a platform for monoclonal antibody
caninization, murinization and humanization services.